巨噬细胞与心肌纤维化的研究进展

Research progress in macrophage and myocardial fibrosis

巨噬细胞作为数量最多的白细胞之一,在组织的损伤和修复中发挥着重要的免疫作用。心肌纤维化是高血压病、糖尿病心肌病、心肌梗死等常见疾病的病理生理过程,在心肌纤维化过程中,巨噬细胞可以通过多种途径来改变细胞胶原蛋白的表达,如调节细胞因子和生长因子的合成与分泌,影响自身的吞噬作用及改变自身极化状态等引起心肌纤维化的发生。以巨噬细胞作为靶点,从而预防和改善心肌纤维化,可能成为新的治疗措施。

Macrophages,one of the most abundant white blood cells,play an important immune role in tissue damage and repair.Myocardial fibrosis is pathophysiological process of hypertension,diabetic cardiomyopathy,myocardial infarction and other common diseases.In the process of myocardial fibrosis,macrophage can alter the expression of collagen protein through a variety of ways,such as adjusting the synthesis and secretion of cytokines and growth factors,affecting their phagocytosis and polarization caused by the occurrence of myocardial fibrosis.Targeting macrophages may be a new therapeutic approach to preventing and improving myocardial fibrosis.