免疫检查点抑制剂相关心脏毒性的研究进展

Research pregress in immune checkpoint inhibitors and cardiotoxicity

免疫检查点抑制剂(ICI)通过阻断肿瘤细胞的免疫逃逸,调动自身免疫反应达到治疗肿瘤的目的。ICI可导致多种免疫相关不良反应,其中心脏毒性是少见但致命的不良反应。随着ICI在临床中使用的增加,其导致的心脏毒性逐渐引起更多关注。本文就ICI相关心脏毒性临床表现、机制、诊治及预后进行综述。

By blocking the immune escape of tumor cells,immune checkpoint inhibitors(ICI)can activate immune response to attack tumor cells.ICI also causes a variety of immune related adverse events,among which cardiotoxicity is a rare but fatal one.With the increasing clinical use of ICI,cardiotoxicity attracts more attention.This article reviewed clinical manifestation,mechanism,diagnosis,treatment and prognosis of ICI induced cardiotoxicity.