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hnRNP U在恶性肿瘤中的研究进展

Research Progress of hnRNP U in Malignant Tumors
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摘要 核不均一性核糖核蛋白(hnRNP)是真核细胞mRNA调控过程中的关键因子,通过干预mRNA的功能从而调控细胞的多种生物过程。其中,hnRNP U为hnRNP家族的重要成员,在多种恶性肿瘤的发生发展过程中发挥了重要作用。本文通过总结近年来hnRNP U的相关研究,对hnRNP U的功能及其在几种恶性肿瘤中的作用进行综述,并对hnRNP U在恶性肿瘤中潜在的诊断及治疗价值进行讨论。 Heterogeneous nuclear ribonucleoprotein(hnRNP)is a key factor in the regulation of mRNA in eukaryotic cells,which interferes with the function of mRNA and thus effects vari ous biological processes in cells.Among them,hnRNP U is an important member of the hnRNP family and plays an important role in the development of various malignant tumors.In this paper,we reviewed the relevant studies on hnRNP U in recent years by summarizing the function of hnRNP U in several malignant tumors,and discuss the potential diagnostic and therapeutic value of hnRNP U in malignant tumors.
作者 李梦园 孔令非 LI Mengyuan;KONG Lingfei(Department of Oncology,Zhengzhou University People's Hospital,Zhengzhou 450003,China;Pathology,Zhengzhou University People's Hospital,Zhengzhou 450003,China)
机构地区 郑州大学人民医院肿瘤内科 郑州大学人民医院病理科
出处 《河南医学研究》 CAS 2022年第7期1340-1344,共5页 Henan Medical Research
基金 河南省重大科技专项(161100311400)。
关键词 核不均一性核糖核蛋白家族 核不均一性核糖核蛋白U 恶性肿瘤 剪接因子 heterogeneous nuclear ribonucleoprotein group heterogeneous nuclear ribonucleoprotein U malignant neoplasm splicing factor
分类号 R730 [医药卫生—肿瘤]
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河南医学研究
2022年 第7期

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