大麻素受体2在慢性疼痛中的研究进展

Research progress of cannabinoid receptor2in chronic pain

慢性疼痛是一种独立的疾病,其临床诊疗现状极不乐观,给人们带来了沉重的经济负担和心理负担。目前,为寻求理想的镇痛靶点,人们已经不断关注对机体具有重要作用的大麻素受体2(cannabinoid receptor 2,CB2)。CB2可通过外周免疫细胞和小胶质细胞发挥镇痛作用,而不造成严重的精神性不良反应,使其在基础研究中将成为备受关注和治疗慢性疼痛中最具潜力的镇痛靶点之一。为此,本文就CB2在慢性疼痛的研究进展进行综述。

Chronic pain is an independent disease.The current situation of its clinical diagnosis and treatment is not optimistic,which has brought heavy economic and psychological burden to people.At present,in order to seek ideal analgesic target,cannabinoid receptor 2(CB2),which plays an important role in the body,has attracted increasing attention.Many studies in pain medicine have shown that CB2 can exert analgesic effects through peripheral immune cells and microglia without causing serious psychiatric side effects.Therefore,it will become one of the most promising analgesic targets in the treatment of chronic pain in basic research.This article reviews the research progress of cannabinoid receptor 2 in chronic pain.