异戊烯基黄酮类化合物抗炎作用的研究进展

A review of anti-inflammatory effects of isopentenyl flavonoids

异戊烯基黄酮类化合物是一类重要的黄酮衍生物,其特点是在黄酮母核的不同原子位置上有异戊烯基的取代,且结构多样,相较于黄酮类化合物具有更强的抗炎、抗骨质疏松、抗肿瘤、抗氧化等药理学作用。根据异戊烯基在母核中取代位点、取代基的数量和结构类型的不同,将异戊烯基黄酮类化合物分为3-异戊烯基取代黄酮类、5-异戊烯基取代黄酮类、6-异戊烯基取代黄酮类、8-异戊烯基取代黄酮类、多异戊烯基取代黄酮类、吡喃环异戊烯基取代黄酮类等六种类型。本综述概括并总结了这六种类型的异戊烯基黄酮类化合中具有抗炎作用的代表性化合物及其相关作用机制,以期为异戊烯基黄酮类化合物治疗骨关节炎等炎症性疾病提供理论依据,从而为研究开发新的异戊烯基黄酮类药物提供参考。

Isopentenyl flavonoids are a class of important flavonoids derivatives,which are characterized by the substitution of isopentenyl groups at different atomic positions in the parent nucleus of flavonoids,and they are with structural diversity.It has better pharmacological effects such as anti-inflammatory,anti-osteoporosis,anti-tumor and anti-oxidation compared with other flavonoids.According to the different substitution sites,numbers and structure types of isopentenyls in the nucleus,isopentenyl flavonoids were divided into six types:3-isopentenyl substituted flavonoids,5-isopentenyl substituted flavonoids,6-isopentenyl substituted flavonoids,8-isopentenyl substituted flavonoids,polyisopentenyl substituted flavonoids and pyran ring isopentenyl substituted flavonoids.This review briefly summarizes the anti-inflammatory effects and related mechanisms of representative compounds in these six types of isopentenyl flavonoids,in order to provide a theoretical basis for the treatment of inflammatory diseases such as osteoarthritis by isopentenyl flavonoids,and provide references for the research and development of new isopentenyl flavonoids drugs.