摘要
CCM3(Cerebral caverrnous malformation 3,CCM3)是脑海绵状血管瘤(Cerebral cavernous malformation,CCMs)的第3个致病基因,对血管生成发育和维持血管完整性有重要作用。研究表明,CCM3基因突变可引起多种血管病变,该基因在血管相关疾病诊治中的作用存在挖掘潜力。本文综述了CCM3基因调控细胞增殖、凋亡、迁移、细胞力学、紧密连接和炎症反应等机制及其影响血管相关疾病的作用,为探索血管疾病的CCM3基因治疗手段提供思路。
Cerebral caverrnous malformation 3(CCM3) is the third pathogenic gene of cerebral cavernous hemangioma(CCMs), which plays an important role in angiogenesis and vascular integrity. Studies have shown that mutations in CCM3gene can cause multiple vascular diseases. Therefore, this gene has potential in the diagnosis and treatment of vascular related diseases. This review summarizes the mechanisms by which the CCM3 gene regulates cell proliferation, apoptosis,migration, cell mechanics, tight junctions, and inflammatory responses, and influencing the effects of vascular related diseases and providing insights into the means of CCM3 gene therapy for vascular diseases.
作者
李晨薇
黄坤
周兴业
张小康
高艳芳
LI Chen-wei;HUANG Kun;ZHOU Xing-ye;ZHANG Xiao-kang;GAO Yan-fang(School of Public Health and Health Management,Gannan Medical University,Ganzhou,Jiangxi 341000)
出处
《赣南医学院学报》
2022年第2期159-163,共5页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金
国家自然科学基金项目(81903364)
江西省自然科学基金项目(20202BABL206123)
心脑血管疾病防治教育部重点实验室开放课题(XN201918)。
关键词
CCM3
血管生成
肿瘤
Cerebral caverrnous malformation 3(CCM3)
Angiogenesis
Tumor