磁共振扩散峰度成像在鼻咽癌中的研究进展

Advances in magnetic resonance diffusion kurtosis imaging in nasopharyngeal carcinoma

鼻咽癌(NPC)是头颈部较为常见的恶性肿瘤之一,早期临床症状多为头痛及颈部淋巴结的肿大,就诊时已多为中晚期,肿瘤的局部复发及远处转移为临床治疗预后带来了困扰。磁共振的形态学成像与功能性成像已广泛地应用于各种肿瘤的诊断及治疗中,其中扩散峰度成像(DKI)是1种建立在扩散加权成像(DWI)及扩散张量成像(DTI)基础上的新兴磁共振扩散成像技术,能够无创性地对活体组织中水分子的扩散进行检测,从而反映复杂的生物组织微观结构,在NPC的诊断、疗效评估及预测等方面表现出了潜在的能力。本文旨对DKI在NPC中的研究进展进行综述。

Nasopharyngeal carcinoma(NPC)is one of the common malignant tumors of the head and neck.The early clinical symptoms are usually headache and enlargement of neck lymph nodes,and most of them are in the middle and advanced stage at the time of diagnosis.The local recurrence and distant metastasis of the tumor bring confusion to the clinical prognosis.The morphological and functional imaging of magnetic resonance has been widely used in the diagnosis and treatment of various tumors.Among them,diffusion kurtosis imaging(DKI)is an emerging magnetic resonance diffusion imaging technique based on diffusion-weighted imaging(DWI)and diffusion tensor imaging(DTI).It is capable of non-invasively detecting the diffusion of water molecules in living tissues,thus reflecting the complex microstructure of biological tissues.It has demonstrated potential capabilities in the diagnosis,efficacy assessment and prediction of NPC.The aim of this paper is to review the research progress of DKI in NPC.