细胞焦亡在重要器官缺血再灌注损伤中的研究进展

Research progress of pyroptosis in ischemia-reperfusion injury of vital organs

细胞焦亡作为一种促炎细胞死亡形式,是由Gasdermin(GSDM)介导的细胞程序性坏死,在形态和病理生理上均不同于其他形式的细胞死亡(如凋亡、坏死)。焦亡表现为质膜迅速破裂,进而释放出细胞内容物和促炎介质。随着焦亡机制逐渐被阐释,焦亡被认为是缺血再灌注损伤(IRI)的重要机制之一,细胞焦亡与心、肝、脑、肾IRI发生发展密切相关。了解焦亡信号如何被激活,以及在重要器官IRI中的作用,有助于探索治疗IRI新的方案。

Pyroptosis,as a form of pro-inflammatory cell death,is necroptosis mediated by Gasdermin,which is different from other forms(such as apoptosis and necrosis)in morphology and pathophysiology.It is characterized by the rupture of cell membrane and release of cell contents and pro-inflammatory mediators.With the gradual explanation of the mechanism of pyroptosis,it is considered to be one of the important mechanisms of ischemia-reperfusion injury(IRI).Pyroptosis is closely related to the occurrence and development of IRI of heart,liver,brain and kidney.Understanding how the pyroptosis signal is activated and its role in the IRI of important organs is helpful to explore a new scheme for the treatment of IRI.This review focused on the role of pyroptosis in IRI of vital organs.