超声引导下穿刺活检结合基因检测在PTC诊断中的应用

Application of Ultrasound-guided Needle Biopsy Combined With Gene Detection in the Diagnosis of PTC

目的分析超声引导下细针穿刺活检结合BRAFV600E检测在甲状腺乳头状癌诊断中的应用价值。方法选取于2018年6月—2021年6月的疑似甲状腺乳头状癌患者50例,分析超声引导下细针穿刺活检技术结合BRAFV600E检测在诊断甲状腺乳头状癌中的特异度、灵敏度、阳性结果预测值和阴性结果预测值。结果参与研究的50例患者中,经术后病理组织学检测发现,有18例患者为良性甲状腺结节,有32例患者为甲状腺乳头状癌,细针穿刺活检与BRAFV600E检测在诊断甲状腺乳头状癌的灵敏度上差异有统计学意义(P<0.05);与单纯的进行细针穿刺和BRAFV600E检测相比,细针穿刺结合BRAFV600E检测,在诊断甲状腺乳头状癌的灵敏度及阴性结果预测值上差异有统计学意义(P<0.05)。结论超声引导下细针穿刺活检结合BRAFV600E检测可较好地提高甲状腺乳头状癌的临床诊断准确率。

Objective To analyze the value of ultrasound-guided fineneedle biopsy combined with BRAFV600E detection in the diagnosis of papillary thyroid carcinoma(PTC).Methods Fifty patients with suspected papillary thyroid carcinoma were selected from June 2018to June 2021,analyzed the specificity,sensitivity,predictive value of positive results and predictive value of negative results of ultrasoundguided fine needle biopsy combined with BRAFV600E in the diagnosis of papillary thyroid carcinoma.Results Fine needle aspiration biopsy and BRAFV600E were used to diagnose papillary thyroid.There was a significant difference in the sensitivity of cancer(P<0.05);compared with simple fine needle aspiration and BRAFV600E detection,the combination of fine needle aspiration and BRAFV600E detection can be used in the diagnosis of papillary thyroid carcinoma and the predictive value of negative results.The difference was statistically significant(P<0.05).Conclusion Ultrasound-guided fine-needle aspiration biopsy combined with BRAFV600E detection can improve the accuracy of clinical diagnosis of papillary thyroid carcinoma.