甲状腺激素对适应性免疫细胞的作用

Functions of Thyroid Hormones in Adaptive Immune Cells

甲状腺激素(Thyroid hormones,THs)参与免疫功能的调节,在固有免疫和适应性免疫中发挥着重要作用。THs异常分泌所致的免疫功能失调被认为参与了格雷夫斯病和桥本甲状腺炎等自身免疫性疾病的发生发展。目前,THs在固有免疫细胞(中性粒细胞、巨噬细胞、树突状细胞、自然杀伤细胞、肥大细胞)中的作用已得到了较好的阐明,但THs对适应性免疫细胞(T淋巴细胞与B淋巴细胞)的影响等方面的研究仍未引起足够的重视。因此,本研究从适应性免疫细胞的角度出发,重点讨论了THs对这些细胞的发育、分化及功能等方面的影响,为进一步理解THs调节免疫功能的作用提供新视角。

Thyroid hormones(THs) are implicated in the modulation of immune function, and play a pivotal role in innate and adaptive immunity. The immune dysfunction caused by abnormal secretion of THs is considered to be involved in the pathogenesis of autoimmune diseases such as Graves’ disease and Hashimoto’s thyroiditis. Recently, the actions of THs in innate immune cells(neutrophils,macrophages, dendritic cells, natural killer cells, mast cells) have been well elucidated. However, how THs affect adaptive immune cells(T lymphocytes and B lymphocytes) still remains ill-defined. Therefore, particularly focusing on the adaptive immune cells, this review will highlight the effects of THs on the development, differentiation and function of these cells, and provide a new perspective for better understanding the mechanisms by which THs modulate immune function.