有毒中药甘遂的本草考证

Textual research of the toxic herb Kansui Radix

目的探究古代本草中有毒中药甘遂的基原、产地、炮制与毒性,为研究应用提供参考。方法查阅古代本草专著,考证甘遂的名称、基原、产地、炮制与毒性,进行比较梳理,并结合现代文献研究进行深入探索。结果甘遂药材在历史发展中名称、基原、功效未发生明显变化,产地最早为今山西大同山中,现在以陕西产量大、质量佳。甘遂为有毒药材,为降低毒性,保障用药安全,历代本草中记载了多种炮制方法。甘遂为“泄水之圣药”,有毒,虚者忌用。不可过服,中病即止。结论通过对中药甘遂进行考证,认清用药历史,避免临床使用出现中毒情况,为规范市场流通和统一使用方法奠定基础。

Objective To investigate the origin,concoction and toxicity of the toxic herb Kansui Radix,and to provide reference for research application.Methods This study made a systematic textual research on the historical evolution and changes of the name,origin,producing areas,harvesting time,processing methods and toxicity of Kansui Radix,compared them,and explored them in depth with modern literature.Results The name,origin and efficacy of Kansui Radix had not changed significantly during its historical development.Kansui Radix was a toxic herb,in order to reduce the toxicity and ensure the safety of the medicine,a variety of processing methods had been recorded in the various ancient documents.Kansui Radix was the"holy medicine of draining water",it was toxic and should not be used on the weak.It should not be taken excessively,and it should be stopped when it was sick.Conclusion By examining the Chinese herbal medicine Kansui Radix,we can identify the history of its use,avoid poisoning in clinical use,and lay the foundation for regulating the market circulation and unifying its use.