257例盐酸利多卡因注射液牙科用药不良反应分析

257 cases of adverse drug reactions induced by lidocaine hydrochloride injection used in dentistry

目的分析盐酸利多卡因注射液在牙科用药致药品不良反应(ADR)发生特点,为临床合理用药提供依据。方法筛选2009年1月1日~2019年12月31日山东省ADR数据库中牙科用盐酸利多卡因注射液ADR报告257例,汇总分析。结果盐酸利多卡因注射液ADR多在10 min内发生,累及全身多个系统,以中枢和外周神经系统及精神障碍、心血管系统、全身性为主。结论医护人员应重视牙科用盐酸利多卡因注射液ADR;生产企业应及时修订和完善药品说明书安全性信息。

Objective To analyze the features of adverse drug reaction(ADR)induced by lidocaine hydrochloride injection used in dentistry in order to provide data for rational use of drugs in clinic.Methods Two hundred and fifty-seven cases of ADR caused by lidocaine hydrochloride injection used in dentistry that were collected from January 1,2009 to December 31,2019 in the Shandong provincial ADR monitoring system were analyzed.Results ADR induced by lidocaine hydrochloride injection usually occurred within ten minutes of medication.Multiple systems were affected,including the central system,peripheral nervous system and the cardiovascular system.Conclusion Health care providers should be alert to ADR induced by lidocaine hydrochloride injection used in dentistry.Drug manufacturers should revise and improve the safety information in drug instructions promptly.