西地兰、胺碘酮治疗急诊危重症合并快速心律失常的随机对照研究

Randomized Controlled Study of Cedilanid and Amiodarone in Treatment of Critically Ill Emergency Patients with Tachyarrhythmia

目的:分析在急诊危重症合并快速心律失常患者中使用胺碘酮进行治疗的临床价值。方法:经长沙市第四医院医学学术委员会审批,回顾分析我院急诊科于2020年1月-2021年1月收治的危重症合并快速心律失常的患者112例为研究对象,随机数字分为对照组与观察组,各56例。对照组采用西地兰进行治疗,观察组采用胺碘酮进行治疗。比较患者治疗前后的心功能情况与并发症情况。结果:分别进行治疗后,观察组E峰显著低于对照组,A峰显著高于对照组,E/A值显著低于对照组,差异均有统计学意义(P=0.001)。左心室舒张末期内径(LVEDD)显著高于对照组,左室射血分数(LVEF)显著低于对照组,差异均有统计学意义(P=0.001)。统计并发症的发生情况,观察组的发生率较低,低于对照组,差异有统计学意义(P<0.05)。结论:使用胺碘酮用于改善急诊危重症合并快速心律失常问题,能够发挥一定的改善心律失常的功效,并减少并发症的发生。

Objective: To analyze the clinical value of amiodarone in the treatment of critically ill emergency patients with tachyarrhythmia. Methods: A retrospective analysis of 112 patients with tachyarrhythmia admitted to the emergency department of our hospital from January 2020 to January 2021 was performed upon the approval by the Medical Academic Committee of the Fourth Hospital of Changsha. Using random numbers, the patients were divided into control group and observation group, with 56cases in each group. The control group was treated with cedilanid and the observation group was treated with amiodarone. The patient’s heart function and complications before and after treatment were compared. Results: After treatment, the E peak of the observation group was significantly lower than that of the control group, the A peak was significantly higher than that of the control group, and the E/A value was significantly lower than that of the control group. The differences were statistically significant(P=0.001). The left ventricular end-diastolic diameter in the observation group was significantly higher than that of the control group,and the left ventricular ejection fraction was significantly lower than that of the control group, and the difference was statistically significant(P=0.001). By statistics, the incidence of complications in the observation group was lower than that in the control group,with statistical significance(P<0.05). Conclusion: Amiodarone can improve tachyarrhythmia and reduce complications in critically ill emergency patients with tachyarrhythmia.