短时多次蓝光照射治疗新生儿高胆红素血症效果分析

Effect Analysis of Short-Time Multiple Blue Light Irradiations on Neonatal Hyperbilirubinemia

目的:探讨短时多次蓝光照射治疗新生儿高胆红素血症的临床效果。方法:收集邳州市人民医院2019年1月-2021年11月治疗的100例新生儿高胆红素血症患儿,随机分成试验组和对照组各50例,两组均给予加强营养、病因治疗、保温等措施,口服茵栀黄溶液3 mL/次,3次/d,连续服用7 d。对照组给予持续蓝光照射,蓝光照射时间持续18 h,暂停6 h,连续照射3 d。试验组则采取多次蓝光照射,2次/d,8 h/次,间隔4 h进行第2次照射,连续照射3 d。结果:两组患儿治疗前血清总胆红素比较无显著性差异,治疗2 d和3 d后试验组血清总胆红素明显下降,远低于对照组,差异有统计学意义(P<0.05);两组患儿治疗前血清C反应蛋白、血清转铁蛋白比较无显著性差异,治疗后试验组与对照组相比,血清C反应蛋白明显下降,血清转铁蛋白明显升高,差异有统计学意义(P<0.05);两组患儿治疗前血清S100β蛋白和血清神经元特异性烯醇化酶比较无显著性差异,治疗后试验组均明显下降,远低于对照组,差异有统计学意义(P<0.05)。结论:短时多次蓝光照射治疗新生儿高胆红素血症临床效果显著,值得推广。

Objective: To investigate the clinical effect of short-time multiple blue light irradiations in treatment of neonatal hyperbilirubinemia. Methods: A total of 100 cases of neonatal hyperbilirubinemia treated in Pizhou People’s Hospital from January 2019 to November 2021 were selected and randomly divided into experimental group and control group, with 50 cases in each group. All patients in two groups were given measures such as enhanced nutrition, etiological treatment, temperature maintenance,as well as oral administration of Yinzhihuang Solution, 3 mL/once, 3 times/day, for successive 7 days. The control group was given continuous blue light irradiation for 18 hours, followed by a rest for 6 hours, for continuous 3 days. The experimental group was given multiple blue light irradiations, twice/d, 8 hours/once, and the second irradiation was performed at an interval of 4 hours, for continuous 3 days. Results: Before treatment, there was no significant difference in serum total bilirubin of patients between two groups, and after 2 and 3 days of treatment, serum total bilirubin in the experimental group decreased obviously, which was far lower than that in the control group, and the difference was statistically significant(P<0.05);before treatment there was no significant difference in serum C-reactive protein and serum transferrin of patients between two groups, and after treatment, serum C-reactive protein significantly decreased and serum transferrin increased significantly in the experimental group compared with the control group, and the difference was statistically significant(P<0.05);before treatment, there was no significant difference in serum S100β protein and serum neuron specific enolase of patients between two groups, and after treatment, the above indexes in the experimental group were significantly decreased, which were far lower than those in the control group, and the difference was statistically significant(P<0.05). Conclusion: Short-time multiple blue light irradiations in the treatment of neonatal hyperbilirubinemia has significant clinical effect, and is worthy of promotion.