建立可用于腔内影像学技术检测的兔颈动脉支架后新生动脉粥样硬化的模型

Establishing rabbit model of neo-atherosclerosis after carotid stenting available for intracavitary imaging

近年来,随着腔内影像学的发展,尤其是分辨率达到微米水平的光学相干断层成像(OCT)技术运用于临床及基础研究,越来越多的影像学报告显示支架内新生动脉粥样硬化(ISNA)是支架植入后支架内再狭窄及晚期支架内血栓的重要原因,并且此结果与病理结果具有高度一致性。本综述将详细阐述在探寻ISNA形成机制及斑块特点的过程中,建立兔颈动脉支架内新生动脉粥样硬化模型的过程,为广大科研工作者建立动物模型提供参考。

In recent years,along with intracavitary imaging develops,especially optical coherence tomography(OCT)with microns level resolution applied in clinic and fundamental study,more and more imaging reports indicate that in-stent neo-atherosclerosis(ISNA)is an important cause of in-stent restenosis after stenting and late in-stent thrombosis,and this outcome is highly consistent with pathological results.The present review will elaborate process of establishing rabbit model of carotid in-stent neo-atherosclerosis during exploring ISNA formation mechanism and plaque characteristic,and provide reference on establishing animal model for scientific research workers.