一起社区诺如病毒感染疫情调查及病毒基因型分析

Investigation and genotype analysis of norovirus infection in a community

目的调查某社区一起感染性腹泻疫情原因,分析病原基因型,为防控感染性腹泻疫情提供科学依据。方法2020年11月,采取病例定义、病例搜索、个案流行病学调查、病例对照研究、采集肛拭子检测等方法,对合肥市X小区感染性腹泻疫情开展调查,并利用分子生物学与生物信息学技术分析病原基因型。结果该起事件共报告13例患者,罹患率为0.14%(13/9102);样本检测结果显示为诺如病毒,基因进化分析为诺如病毒GⅡ.4[P31]型。结论本起事件为诺如病毒引起的感染性腹泻疫情,最可能的传播途径为社区外环境接触传染,源头可能是由社区外传入。

Objective To investigate the cause of an epidemic of infectious diarrhea in a community and analyze the pathogen genotypes,providing scientific basis for the prevention and control of epidemic of infectious diarrhea.Methods A infectious diarrhea broke out in community X in Hefei in November 2020.The case was investigated by means of case definition,case search,epidemiological investigation,case-control research and anal swab detection,and the pathogen genotypes were analyzed by molecular biology and bioinformatics techniques.Results A total of 13 patients were reported in this case,with a morbidity rate of 0.14%(13/9102).The results showed that the samples were norovirus,and the genetic evolution analysis was norovirus GII.4[P31].Conclusions This incident is an outbreak of infectious diarrhea caused by norovirus.The most likely route of transmissionis outside the community,and the source may have been introduced from outside the community.