持续炎症-免疫抑制-分解代谢综合征研究新进展

New research progress of persistent inflammation-immunosuppression-catabolic syndrome

持续炎症-免疫抑制-分解代谢综合征(persistent inflammation immunosuppression catabolism syndrome,PICS)是指机体在严重创伤、感染、烧伤等重大疾病打击后发展为慢性危重病(chronic critical illness,CCI)阶段,表现出以持续性炎症反应、免疫抑制、蛋白质高分解代谢为特征的一组临床症候群。

Persistent inflammatory-immunosuppressive-catabolic syndrome(PICS) is a group of clinical syndromes characterized by persistent inflammatory response, immunosuppression and the protein catabolic responses, which develops into chronic critical illness(CCI) after severe trauma, infection, burn and other major diseases. Because its pathogenesis is complex and clinical prevention and treatment is difficult, PICS is the main cause of prolonged hospitalization and long-term death of patients in intensive care unit(ICU). The decline of their quality of life requires long-term acute cares(LTACs), and will eventually experience chronic failure and death. However, the pathogenesis of PICS is complex, clinicians are relatively lack of awareness and vigilance of PICS, resulting in a high incidence and poor long-term prognosis. Therefore, how to improve clinicians’ vigilance to PICS and effectively improve the survival rate of patients after discharge has become a great challenge for contemporary medicine. The main purpose of this paper is to summarize the pathogenesis, diagnosis and treatment strategies of PICS by combing the understanding of PICS at home and abroad, and thus improve clinicians’ understanding of PICS and provide new ideas for prevention and treatment.