红细胞在网状微血管结构内的运动仿真研究

Simulation of Erythrocyte Movements in Reticular Microvascular Structure

目的本文运用流体力学软件COMSOL Multiphysics建立微血管模型仿真,模拟微血管中红细胞的运动轨迹,计算得出红细胞的速度和位移与时间之间的关系。方法根据微血管系统的网状结构,利用流体力学计算软件COMSOL Multiphysics建立有限元模型,并对粒子轨迹进行处理,得到稳定的数据分析结果。结果随着流速的增大,红细胞运动更加剧烈,速度更快。当流速从100 mL/h逐渐增加至400 mL/h时,粒子在1 s内的平均位移从0.22 cm增大到0.84 cm,并且二者的关系不完全是线性的。结论红细胞在网状微血管结构内的运动仿真为深入了解组织微循环的机制提供了有价值的信息。

Objective To establish the microvessel model simulation,simulate the movement trajectory of erythrocyte in microvessels,and calculate the relationship between the speed and displacement of erythrocyte and time using the fluid dynamics software COMSOL Multiphysics.Methods According to the reticular structure of the microvascular system,the finite element model was established with COMSOL Multiphysics,and the particle trajectory was processed to obtain stable data analysis results.Results With the increase of flow rate,erythrocyte moved more vigorously and faster.When the flow rate increased from 100 mL/h to 400 mL/h,the average displacement of particles increased from 0.22 cm to 0.84 cm within 1 s,and the relationship between them was not completely linear.Conclusion The simulation of erythrocyte movement in reticular microvascular structure provides valuable information for understanding the mechanism of tissue microcirculation.