千斤拔有效成分调控膝骨关节炎进展的相关信号通路

Active components of flemingia in regulating the signaling pathways related to knee osteoarthritis

背景:作为老年性常见疾病,膝骨关节炎病因、发病机制尚未明确,且因其具有高发病率及高致残率特征,需积极防治。研究证实,千斤拔对防治膝骨关节炎有显著疗效,研究其作用机制有着重要意义。目的:查阅国内外相关文献,综述千金拔中有效成分防治膝骨关节炎的研究进展,总结并归纳出与其作用机制相关的信号通路,为有效防治膝骨关节炎提供思路和借鉴。方法:查阅国内外数据库2010-2020年发表的相关文献,检索中国知网、万方、维普、PubMed、MEDLINE、Cochrane和Nature数据库,排除重复及较为陈旧的文献,通过入选和排除标准共纳入60篇文献进行探讨。结果与结论:①千斤拔主要有效成分包括染料木素、豆甾醇、大黄素、大黄酚及芒柄花苷等;②千斤拔的有效成分可以通过一些相关炎性因子等发挥抗炎、促进成骨细胞增殖分化与调控软骨细胞凋亡的作用,其主要调节路径包括Notch、JAK2/STAT3、核转录因子κB及MAPK等相关信号通路,以此延缓膝骨性关节炎病情的加速进展。

BACKGROUND:As a common disease of the elderly,the etiology and pathogenesis of knee osteoarthritis have not been clearly defined,and due to its high incidence and high disability rate,it seriously affects the quality of life of patients,requiring active prevention and treatment.Studies have confirmed that flemingia has a significant effect on the prevention and treatment of knee osteoarthritis;and studying its mechanism is of great significance.OBJECTIVE:By reviewing relevant articles at home and abroad,the research progress of flemingia in the prevention and treatment of knee osteoarthritis was reviewed based on the mechanism-related signaling pathways,providing ideas and reference for the effective prevention and treatment of knee osteoarthritis.METHODS:Relevant articles published from 2010 to 2020 were retrieved on CNKI,Wanfang,VIP,PubMed,MEDLINE,Cochran and Nature databases.A total of 60 articles were included through inclusion and exclusion criteria to exclude duplicated and old articles.RESULTS AND CONCLUSION:(1)The main active components of flemingia include genistein,stigmasterol,emodin,chrysophanol,and ononin.(2)The active components of flemingia play an anti-inflammatory role in promoting osteoblast proliferation and differentiation and regulating chondrocyte apoptosis to delay the accelerated progression of knee osteoarthritis.The main regulatory pathways contain Notch,JAK2/STAT3,nuclear factor-κB,MAPK and other related signaling pathways.