中医体质类型与多囊卵巢综合征相关性的meta分析

Correlation between TCM constitution and polycystic ovary syndrome:a meta-analysis

目的总结中医(TCM)体质类型和多囊卵巢综合征(PCOS)相关研究现状,探讨PCOS患者的中医体质分布规律,为PCOS的中医药防治提供循证医学证据。方法检索中国知网、维普、万方、PubMed、Cochrane、Embase数据库,纳入所有PCOS中医体质类型的临床研究文献。采用Stata 16.0进行meta分析,并分别以率和比值比及其95%可信区间表达效应值。结果共纳入20项研究,累计样本量4928例。结果显示:痰湿质、阳虚质、气郁质和气虚质占PCOS患者的比例分别为15.8%、14.1%、12.5%和12.1%。按地区进行亚组分析显示华中痰湿质、阳虚质和特禀质比例最高,华北血瘀质和气虚质最高,华东气郁质和湿热质最高,华南和华西则分别以平和质和阴虚质为主。PCOS患者与一般人群体质类型比较显示,痰湿质(OR=1.871,95%CI:1.109~3.156,P=0.019),平和质(OR=0.313,95%CI:0.208~0.472,P<0.001),其余体质类型差异无统计学意义。结论痰湿质、阳虚质、气郁质和气虚质是PCOS患者的主要体质类型;痰湿质为PCOS的危险因素,平和质为PCOS的保护因素。

Objective To summarise the research status of traditional Chinese medicine(TCM)constitution types and polycystic ovary syndrome(PCOS),and to explore the distribution of TCM constitution of PCOS patients,so as to provide evidence-based medical evidence for TCM prevention and treatment of PCOS.Methods The databases of CNKI,CQVIP,Wanfang Data,PubMed,Cochrane and Embase were searched,and all clinical research documents of TCM constitution types of PCOS were retrieved.Meta-analysis was carried out with Stata 16.0,and the effect values were expressed in terms of rate,ratio and 95%confidence interval.Results Twenty studies were included with 4928 individuals.The results showed that phlegm-dampness,yang deficiency,qi stagnation and qi deficiency accounted for 15.8%,14.1%,12.5%and 12.1%of PCOS patients,respectively.Subgroup analysis by region showed that the proportion of phlegm-dampness,yang deficiency and special was the highest in Central China,blood stasis constitutions and qi deficiency were the highest in North China,qi stagnation and damp-heat constitutions were the highest in East China,and balanced constitution and yin deficiency were the highest in South China and West China.The comparison of constitution types between PCOS patients and the general population showed that phlegm dampness(OR=1.871,95%CI:1.109-3.156,P=0.019)and peace(OR=0.313,95%CI:0.208-0.472,P<0.001).There was no significant difference in other constitution types.Conclusion Phlegm-dampness,yang deficiency,qi stagnation and qi deficiency are the main constitution types of PCOS patients.Phlegm-dampness is a risk factor of PCOS,and balanced constitution is a protective factor of PCOS.