20 Hz重复经颅磁刺激对阿尔茨海默病的影响及长期作用

Efficacy of 20 Hz repetitive transcranial magnetic stimulation on Alzheimer′s disease and its long-term effects

目的探讨20 Hz重复经颅磁刺激对阿尔茨海默病(AD)患者临床症状的影响及长期作用。方法选取70例AD患者,分成观察组35例和对照组35例。观察组给予20 Hz重复经颅磁刺激治疗,治疗疗程为6周。评估2组治疗前、治疗后及治疗结束12周后认知功能和精神行为症状相关评分。结果治疗后,观察组阿尔茨海默病评定量表-认知(ADAS-Cog)、神经精神科问卷(NPI)评分低于对照组,差异有统计学意义(P<0.05);2组简易智能精神状态量表(MMSE)、日常生活能力量表(ADL)评分比较,差异无统计学意义(P>0.05)。治疗结束12周后,观察组ADAS-Cog、NPI评分低于对照组,MMSE评分高于对照组,差异有统计学意义(P<0.05);2组ADL评分比较,差异无统计学意义(P>0.05)。结论20 Hz重复经颅磁刺激可有效改善AD患者的认知功能和精神行为症状,且在治疗结束后仍有作用。

Objective To explore the impact of 20 Hz repetitive transcranial magnetic stimulation on clinical symptoms in patients with Alzheimer's disease(AD)and its long-term effect.Methods A total of 70 patients with AD were divided into observation group(n=35)and control group(n=35).The observation group was treated with 20 Hz repetitive transcranial magnetic stimulation for 6 weeks.Cognitive function and the scores of psycho-behavioral symptoms were evaluated before treatment,after treatment and 12 weeks after treatment.Results After treatment,scores of Alzheimer′s Disease Assessment Scale-Cognition(ADAS-Cog)and Neuropsychiatric Inventory(NPI)in the observation group were significantly lower than those in the control group(P<0.05).There were no significant differences in Mini-Mental State Examination(MMSE)and activities of daily living(ADL)scale between the two groups(P>0.05).Twelve weeks after treatment,ADAS-Cog and NPI scores in the observation group were significantly lower,and MMSE score was significantly higher than that in the control group(P<0.05).There was no significant difference in ADL score between the two groups(P>0.05).Conclusion 20 Hz repetitive transcranial magnetic stimulation can effectively improve the cognitive function and psycho-behavioral symptoms of AD patients,and the effect remains after the end of treatment.