摘要
目的探讨良性前列腺增生(BPH)患者经尿道前列腺剜除术(TUERP)后血清游离前列腺特异性抗原(fPSA)水平变化及其与前列腺体积、预后的关系。方法将105例行TUERP的BPH患者根据术前的前列腺体积分为小体积组(n=49)、中体积组(n=36)和大体积组(n=20)。比较3组患者术前及术后1、3、7 d时血清fPSA水平。Pearson法分析术前血清fPSA水平与前列腺体积的关系。比较不同预后BPH患者临床资料及术后7 d血清fPSA水平。采用Logistic回归分析探讨BPH患者不良预后的影响因素。结果术前及术后1 d时,小体积组、中体积组、大体积组患者血清fPSA水平呈增高趋势,组间比较差异均有统计学意义(P<0.05)。Pearson法分析结果显示,BPH患者术前血清fPSA水平与前列腺体积呈正相关(r=0.598,P<0.05)。与预后良好组(n=79)相比,预后不良组(n=26)高密度脂蛋白胆固醇(HDL-C)、血糖、术后7 d血清fPSA水平及合并高血压比率均升高,差异有统计学意义(P<0.05)。Logistic回归分析,结果显示HDL-C、血糖、合并高血压、术后7 d血清fPSA均为BPH患者预后的危险因素(P<0.05)。结论BPH患者血清fPSA呈高水平表现,其可能参与影响BPH发病过程。术后7 d血清fPSA水平可评估BPH患者TUERP后的预后情况。
Objective To investigate the change of serum free prostate specific antigen(fPSA)in patients with benign prostatic hyperplasia(BPH)after transurethral enucleative resection of prostate(TUERP)and its relationships with prostate volume and prognosis.Methods A total of 105 BPH patients with TUERP were divided into small volume group(n=49),medium volume group(n=36)and large volume group(n=20)according to preoperative prostate volume.The levels of serum fPSA were compared among three groups before operation and 1 day,3 and 7 days after operation.The relationship between preoperative serum fPSA level and prostate volume was analyzed by Pearson method.The clinical materials and the level of serum fPSA at 7 days after operation were compared among BPH patients with different prognosis.Logistic regression analysis was used to explore the influencing factors of poor prognosis in BPH patients.Results Before operation and 1 day after operation,the levels of serum fP SA in the small volume group,the medium volume group and the large volume group increased significantly(P<0.05).Pearson analysis showed that there was a positive correlation between preoperative serum fP SA level and prostate volume in patients with BPH(r=0.598,P<0.05).Compared with the good prognosis group(n=79),the high density lipoprotein cholesterol(HDL-C),blood glucose,serum fP SA level at 7 days after operation and the ratio of cases with hypertension in the poor prognosis group(n=26)were significantly higher(P<0.05).Logistic regression analysis showed that HDL-C,blood glucose,hypertension and serum fP SA at 7 days after operation were the risk factors for the prognosis of BPH patients(P<0.05).Conclusion The serum fP SA level is highly expressed in BPH patients,which may be involved in the pathogenesis of BPH.The serum fP SA level at 7 days after operation can be used to evaluate the prognosis of BPH patients after TUERP.
作者
曾柯
谢文贤
杨键
李小滨
刘跃江
陈荣
邓克非
王体芬
ZENG Ke;XIE Wenxian;YANG Jian;LI Xiaobin;LIU Yuejiang;CHEN Rong;DENG Kefei;WANG Tifen(Department of Urinary Surgery,Zigong City First People′s Hospital of Sichuan Province,Zigong,Sichuan,643000;Department of Basic Medicine,Sichuan Vocational College of Health and Rehabilitation,Zigong,Sichuan,643000;Department of Anesthesiology,Neijiang City Second People′s Hospital of Sichuan Province,Neijiang,Sichuan,641000)
出处
《实用临床医药杂志》
CAS
2022年第5期39-43,共5页
Journal of Clinical Medicine in Practice
基金
2017年四川省卫生和计划生育科研课题(17PJ233)
四川省自贡市第一人民医院院级课题(CWKY-2018Y-22)。
关键词
经尿道前列腺增生剜除术
良性前列腺增生
游离前列腺特异性抗原
前列腺体积
预后
transurethral enucleative resection of prostate
benign prostatic hyperplasia
free prostate specific antigen
prostate volume
prognosis