血液内源性小分子物质代谢在抑郁症中的研究进展

Recent advance in role of endogenous small molecule substance metabolism in blood samples in depression

抑郁症是一种严重的精神疾病,其风险预测、分类、诊断以及预后一直缺乏充分客观的判断依据。代谢组学是继基因组学和蛋白质组学之后新近发展起来的一门学科,为探索抑郁症的病因、机制、预后和筛选潜在生物标志物提供了新的研究手段。血液中几乎包含机体所有小分子代谢产物,该样本易获得且创伤较小。本文现综述近几年有关抑郁症中血液内源性小分子物质代谢的研究进展,以期为抑郁症代谢组学的研究提供更多的理论依据和探索方向。

Depression is a kind of severe psychiatric disorders whose risk prediction,classification,diagnosis,and prognosis lack sufficient objective basis.Metabolomics is an emerging discipline that is developed recently after genomics and proteomics,which provides new ways for examining the etiology,diagnosis,mechanism,and prognosis,and screening potential biomarkers in depression.Blood samples are easy to obtain and have less trauma,which contains almost all small molecular products in the body.This paper reviews the recent researches of blood endogenous small molecule substance metabolism in depression,in order to provide more theoretical basis and exploration direction for further study of metabolomics of depression.