REGⅣ、ORP150与miRNA-223联合检测对胃癌的诊断价值

Diagnostic Value of Combined Detection of REGⅣ,ORP150 and miRNA-223 in Gastric Cancer

目的研究REGⅣ、ORP150与miRNA-223联合检测对胃癌的诊断价值。方法以126例胃癌患者作为研究对象,另选同期体检正常者126例为对照组。对观察组以及对照组、不同分期以及分化程度胃癌患者的REGⅣ、ORP150与miRNA-223水平进行比较。分别对REGⅣ、ORP150与miRNA-223水平联合检测的诊断效能进行分析。结果观察组患者的REGⅣ、ORP150显著高于对照组,miRNA-223水平显著低于对照组,差异存在统计学意义(P<0.05)。胃癌Ⅰ~Ⅱ期组患者的REGⅣ、ORP150水平显著低于Ⅲ~Ⅳ期组,Ⅰ~Ⅱ期组患者的miRNA-223水平显著高于Ⅲ~Ⅳ期组;随着患者的分化程度的进展,患者的REGⅣ、ORP150水平显著升高,miRNA-223水平显著降低。胃癌的进展(分化程度、TNM分期)与REGⅣ、ORP150呈现正相关,与miRNA-223呈现负相关。REGⅣ、ORP150与miRNA-223水平联合检测对胃癌的诊断灵敏度显著高于单独检测,通过ROC曲线分析,对于胃癌的诊断而言,患者的REGⅣ、ORP150与miRNA-223水平的临界值分别为6.11 ng/mL,10.52 ng/mL以及4.77 fmoL/L。结论REGⅣ、ORP150与miRNA-223联合检测对胃癌的诊断具有重要意义。

Objective To study the diagnostic value of combined detection of REGⅣ,ORP150 and miRNA-223 in gastric cancer.Methods 126 patients with gastric cancer were selected as the research objects,and 126 cases of healthy patients as the control group.The levels of REGⅣ,ORP150 and miRNA-223 in the observation group and the control group,and gastric cancer patients at different stage and differentiation degree were compared.The diagnostic efficacy of combined detection of REGⅣ,ORP150 and miRNA-223 was analyzed.Results The level of REGⅣand ORP150 in the observation group was significantly higher than that in the control group,and the miRNA-223 level was significantly lower than that in the control group(P<0.05).The level of REGⅣand ORP150 in the stageⅠ~Ⅱgastric cancer patients was significantly lower than that in the stageⅢ~Ⅳgastric cancer patients,The level of miRNA-223 in the stageⅠ~Ⅱgastric cancer patients was significantly higher than that in the stageⅢ~Ⅳgastric cancer patients.With the increase of differentiation degree,the level of REGⅣand ORP150 increased,and the miRNA-223 level decreased.The differentiation degree and TNM stage of patients showed positive correlation with REGⅣand ORP150,and negative correlation with miRNA-223.The diagnostic sensitivity of combined detection of REGⅣ,ORP150 and miRNA-223 for patients with gastric cancer was significantly higher than that of single detection.According to ROC curve analysis,the critical values of REGⅣ,ORP150 and miRNA-223 in patients with gastric cancer were 6.11 ng/ml,10.52 ng/ml and 4.77 fmol/L,respectively.Conclusion The combined detection of REGⅣ,ORP150 and miRNA-223 is of great significance in the diagnosis of gastric cancer.