大电导钙激活钾通道对心律失常的影响

Effect of large-conductance Ca^(2+) -activated K^(+) channel on arrhythmias

心律失常是心血管疾病领域的常见病、多发病之一,其发病机制与离子通道密切相关。钾离子通道在心肌细胞电兴奋过程中发挥重要作用。近年来,大电导钙激活钾通道(large-conductance Ca^(2+)-activated K^(+) channel,BK_(Ca)通道)对心律失常的影响成为一个新的研究方向,并受到广泛关注。本文对BK_(Ca)通道的生物学特性及其在心脏组织中的分布、影响心律失常的可能机制进行综述。

Arrhythmia is one of the common and frequently occurring cardiovascular diseases,and its pathogene-sis is closely related to ion channels.K^(+) channels play important roles in the electrical excitation of cardiomyo-cytes.The effect of large-conductance Ca^(2+)-activated K^(+) channel(BK_(Ca) channel)on arrhythmias has become a new direction of research in recent years,and has attracted extensive attention.This paper reviews the biological characteristics of BK_(Ca) channel,its distribution in heart tissues and the possible mechanisms of its effect on arrhyth-mias.