NLRP3炎性小体在慢性气道炎症性疾病中的作用研究进展

Research progress on the role of NLRP3 inflammasome in chronic airway inflammatory diseases

慢性气道炎症性疾病是指因感染或变态反应引起的,由气道结构细胞、多种炎性细胞及细胞因子参与的呼吸道疾病,其病因及具体发病机制复杂多变,迄今为止尚未完全明确。核苷酸结合寡聚化结构域(NOD)样受体家族含热蛋白结构域蛋白3(NLRP3)炎性小体是机体固有免疫的重要组成部分,与多种慢性炎症性疾病的发生发展关系密切。本文主要阐述NLRP3炎性小体的活化机制及其在肺内的表达情况,并以慢性阻塞性肺疾病(COPD)和哮喘为例,总结NLRP3炎性小体在慢性气道炎症性疾病发生发展过程中的活性改变及对病情转归的影响,进而为开发靶向NLRP3炎性小体的药物治疗慢性气道炎症性疾病提供依据。

Chronic airway inflammatory diseases are kinds of respiratory diseases caused by infection or allergy,which are involved in airway structural cells and multiple inflammatory cells and cytokines.Their etiology and specific pathogenesis are complex and changeable,and remain unclear.The nucleotide-binding oligomerization domain(NOD)-like receptor family,pyrin domain-containing protein 3(NLRP3)inflammasome,is an important component of innate immunity and closely correlates with the development and progression of many chronic inflammatory diseases.This article mainly expounds the activation mechanism and pulmonary expression of NLRP3 inflammasome and it’s expression in the lung,and also summarizes its activity change and role during the progression of chronic inflammatory diseases using chronic obstructive pulmonary disease(COPD)and asthma as the examples,to provide a basis for targeting NLRP3 inflammasome to treat chronic airway inflammatory diseases.