内蒙古心血管病高危人群饮酒模式与健康相关生活质量的关系

Association between alcohol consumption pattern and health-related quality of life in individuals with high cardiovascular disease risk in Inner Mongolia,China

目的研究心血管疾病(cardiovascular disease,CVD)高危人群中饮酒模式与健康相关生活质量(health-related quality of life,HRQoL)的关系。方法2015―2017年采用多阶段分层整群随机抽样的方法选择内蒙古自治区(简称内蒙古)6个乡村或社区的常住居民进行横断面研究,研究内容包括问卷调查、体格检查和实验室检测,根据调查结果选择10年CVD发病风险≥10%的人群为高危人群,调查其饮酒模式与HRQoL。饮酒模式和HRQoL分别采用酒精使用障碍量表和欧洲五维健康量表(EuroQol Five-Dmensions Guestionnaire,EQ-5D)进行调查。采用多因素Logistic回归分析模型分析饮酒模式与HRQoL的关系。结果本研究共纳入CVD高危人群12454人,其中不饮酒者占76.8%。与不饮酒者相比,男性中适量饮酒者发生疼痛/不舒服、焦虑/抑郁的风险分别是1.652(95%CI:1.437~1.901,P<0.001)、1.758(95%CI:1.507~2.049,P<0.001);危险性饮酒者发生疼痛/不舒服、焦虑/抑郁的风险分别是1.520(95%CI:1.262~1.831,P<0.001)、1.693(95%CI:1.382~2.073,P<0.001);女性中适量饮酒者发生疼痛/不舒服、焦虑/抑郁的风险分别是1.536(95%CI:1.223~1.930,P<0.001)、1.566(95%CI:1.237~1.982,P<0.001)。结论建议CVD高危人群戒酒以提高其HRQoL。

Objective To investigate the relationship between alcohol use and health-related quality of life(HRQoL)in people who were at high risk of cardiovascular disease(CVD).Methods From 2015 to 2017,permanent residents of 6 villages or settlements in Inner Mongolia were chosen as the research site,using a multi-stage stratified cluster random selection method.The study contents included questionnaire,physical examination and laboratory testing.Participants with a predicted risk of CVD more than 10%were identified as having a high CVD risk.Alcohol use disorders identification test and EuroQol Five-Dmensions Guestionnaire(EQ-5 D)scale were used to investigate drinking patterns and HRQoL in high CVD risk groups.Multivariate Logistic regression was used to investigate the relationship between drinking patterns and HRQoL.Results Of 12454 participants with high CVD risk,76.8%were reported as nondrinkers.Compared with non-drinkers,the OR values of the risk of pain/discomfort and anxiety/depression among men who were low risk drinkers were 1.652(95%CI:1.437-1.901,P<0.001)and 1.758(95%CI:1.507-2.049,P<0.001);the OR values of risk of pain/discomfort and anxiety/depression of hazardous drinkers were 1.520(95%CI:1.262-1.831,P<0.001)and 1.693(95%CI:1.382-2.073,P<0.001).Compared with non-drinkers,the OR values of the risk of pain/discomfort and anxiety/depression among women who were low risk drinkers were 1.536(95%CI:1.223-1.930,P<0.001)and 1.566(95%CI:1.237-1.982,P<0.001).Conclusion It is suggested that those who have high risk of CVD should refrain from alcohol in order to enhance their health-related quality of life.