摘要
Two new neolignans and one new lignan(1-3)were obtained from the roots of Paeonia lactiflora.Their structures were unambiguously elucidated based on extensive spectroscopic analysis,single-crystal X-ray crystallography,and the calculated and experimental electronic circular dichroism(ECD)spectra.Compound 1 was a racemic mixture and successfully resolved into the anticipated enantiomers via chiral-phase HPLC.Compound 3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1(hCES2Al)with an IC_(50) value of 7.28±0.94 μmol·L^(-1).
基金
supported by the National Natural Science Foundation of China(Nos.81773589 and 82073978)
Beijing Natural Science Foundation(No.JQ18026)
the Innovation Platform for the Development and Construction of Special Project of Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province(No.2020-ZJ-Y20).
