生物钟Bmal1基因与慢性代谢性疾病及其运动干预研究进展

Biological Clock Bmal1 Gene and Chronic Metabolic Diseases and Exercise Intervention Research Progress

脑和肌肉芳香烃受体核转运样蛋白1基因(brain and muscle arnt-like 1,Bmal1)是生物钟的核心基因,在机体生命活动中发挥重要调控作用。生物钟的紊乱通常伴随Bmal1的异常表达,进而诱发一系列慢性代谢性疾病。运动可上调Bmal1表达,减缓慢性代谢性疾病的发病进程。本文主要对生物钟Bmal1在慢性代谢性疾病中的作用及其运动干预研究进展进行综述,提出Bmal1在运动改善慢性代谢性疾病中的可能作用机制,以期为运动通过生物钟基因防治慢性代谢性疾病提供新视角。

Brain and muscle arnt-like protein 1(Bmal1)is the core gene of biological clock,which belongs to the transcription factor family of b HLH-PAS(basic helix-loop-helix-per-arnt-sim)domain.It can regulate the circadian rhythm through its own expression and the transcription-translation feedback regulation of the biological clock,which plays an important role in the life activities of organism.The disorder of biological clock induces a series of chronic metabolic diseases,such as cardiovascular diseases,hepatopathy and neurodegenerative diseases,usually accompanied by abnormal expression of Bmal1.Exercise may up-regulate Bmal1 expression in peripheral tissues and organs to improve chronic metabolic diseases.Different exercise loads and types of exercise,such as aerobic exercise,resistance exercise,will lead to the differential expression of Bmal1.There are many potential mechanisms of Bmal1 in improving chronic metabolic diseases by exercise intervention,such as reducing inflammation and oxidative stress,regulating autophagy,maintaining mitochondrial quality and function,interacting with exerkines and micro RNA.This article reviews the physiological function of Bmal1 in multiple tissues and organs and the relationship between corresponding chronic metabolic diseases,discussing the influence of exercise intervention on Bmal1 expression deeply and putting forward the potential mechanism of Bmal1 in improving chronic metabolic diseases by exercise,in order to provide a new perspective for exercise as a non-drug treatment to prevent and treat chronic metabolic diseases.