摘要
生物来源的胶原蛋白、明胶、纤维蛋白原、纤维素、淀粉以及壳聚糖等材料,因为其无毒性、良好的生物相容性、生物可降解性以及促凝血活性越来越受到研究者的青睐,成为更加优异的止血选择。本文综述目前止血材料的几种类型及相应的止血机理,重点讨论上述生物来源止血材料的基本结构、止血机理、市售产品及最新科研进展,并对其发展前景进行展望。
Bio-derived materials,such as collagen,gelatin,fibrinogen,cellulose,starch and chitosan etc,are attracting more and more attention for being used as hemostatic materials due to their excellent biocompatibility,biodegradability and procoagulant activity.This review discusses several types of hemostatic materials and the corresponding hemostatic mechanisms.Our focus is tailored towards the basic structure,hemostatic mechanism,commercial products and the latest scientific research progress of the above-mentioned bio-derived hemostatic materials.Finally,the tendencies of their development are prospected.
作者
于乐军
刘晨光
YU Le-Jun;LIU Chen-Guang(College of Marine Life Sciences,Ocean University of China,Qingdao 266001,China)
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2022年第3期572-583,共12页
Progress In Biochemistry and Biophysics
基金
国家重点研发计划(2018YFC0311102)资助项目。
关键词
创伤
生物衍生
止血材料
止血机理
wound
bio-derived
hemostatic materials
hemostatic mechanism
