基因甲基化在HIV合并Hr-HPV感染人群宫颈疾病筛查中的研究进展

Research progress of gene methylation in cervical disease screening on HIV and Hr-HPV co-infected people

感染HIV的女性发生高危型人乳头瘤病毒持续感染、多重感染、子宫颈高级别鳞状上皮内病变或宫颈癌的风险高于普通人群。有研究发现,基因甲基化状态在一定程度上与子宫颈鳞状上皮内病变的发生发展具有相关性,对子宫颈高级别鳞状上皮内病变及宫颈癌具有较高的检出率,已逐渐成为预测宫颈疾病精准诊断及个性化治疗的特异性生物标志物。将基因甲基化检测应用于HIV合并高危型人乳头瘤病毒感染的人群中,以期尽早发现及诊断宫颈疾病,为AIDS患者的临床宫颈癌筛查诊治工作提供新思路。本文对基因甲基化检测在HIV合并高危型人乳头瘤病毒感染人群中的应用进展做一综述和讨论,旨在为宫颈疾病的精准诊治提供新思路。

The risk of the occurrence of the high-risk human papillomavirus persistent infection,multiple infections,high-grade squamous intraepithelial lesion and cervical cancer among HIV infected women is higher than the general population.Studies have found that gene methylation status correlates with the development of high-grade squamous intraepithelial lesions to a certain extent.Furthermore,the detection rate is higher,gradually becoming a specific biomarker for predicting accurate diagnosis and personalized treatment of cervical diseases.Gene methylation detection was used in people infected HIV in high-risk human papillomavirus persistent infection to find and diagnose cervical diseases as early as possible and provide new ideas for clinical cervical cancer screening and diagnosis for AIDS patients.This paper reviewed the progress in gene methylation detection in HIV and Hr-HPV co-infected people.We aimed to provide new ideas for cervical disease diagnosis and treatment accuracy.