神经梅毒实验室检测指标研究进展

Research progress of laboratory diagnostic methods on neurosyphilis

神经梅毒是由梅毒螺旋体侵犯中枢神经系统所引起的一组临床综合征。近年随着HIV合并梅毒感染率上升,神经梅毒的临床表现越来越多样化,常需结合实验室检查以明确诊断。但目前实验室检查缺乏敏感性和特异性均高的指标,需寻找新指标以满足临床需求。本文从现有指南诊断指标,病原学检查,炎症和免疫反应指标以及其他指标方面,对神经梅毒实验室诊断指标现状和潜在实验室指标进行综述,旨在为神经梅毒实验室指标的临床应用提供参考,并为科学研究提供思路。

Neurosyphilis is an infection of the central nervous system caused by Treponema pallidum.In recent years,the clinical manifestations of neurosyphilis are becoming more and more diverse with the increasing cases of HIV coinfection with syphilis.Neurosyphilis diagnosis often needs to combine with laboratory examination.However,the current methods could not meet the clinical needs because of their low sensitivity and specificity.So new ways are expected to be explored.We reviewed the current and potential laboratory examination indicators throngh current diagnostic method,etiological detection,inflammatory and immunological indicators.reviewed The article aims to give a new perspective and reference to clinical application and research for laboratory examinations of neurosyphilis.