远隔缺血预适应对脑小血管病患者认知功能障碍的影响

Effect of remote ischemic preconditioning on cognitive dysfunction in patients with cerebral small vessel disease

目的:探讨脑小血管病(CSVD)患者应用远隔缺血预适应(RIPC)治疗对其认知功能障碍的影响。方法:抽取2021年1月至2021年9月赤峰市医院收治的CSVD患者120例,以随机数字表法分为观察组与对照组,每组60例。对照组采用常规药物治疗,观察组在此基础上加用RIPC治疗。比较两组治疗前后血清炎症因子、认知功能及生活质量情况。结果:治疗前,两组血清炎症因子水平、认知功能及生活质量比较差异未见统计学意义( P>0.05)。治疗6个月后,观察组C反应蛋白、肿瘤坏死因子-α、白细胞介素-16水平均低于对照组( P均<0.05),简易精神状态量表评分与蒙特利尔认知量表评分均高于对照组( P均<0.05),躯体功能、物质功能、心理功能、社会功能评分均高于对照组( P均<0.05)。 结论:CSVD患者应用RIPC治疗,可更好地改善其认知功能障碍,促进血清炎症因子水平下降并提高患者的生活质量。

Objective To investigate the effect of remote ischemic preconditioning(RIPC)treatment on cognitive dysfunction in patients with cerebral small vessel disease(CSVD).Methods A total of 120 CSVD patients treated in Chifeng Hospital from January 2021 to September 2021 were enrolled,and they were divided into observation group and control group by random number table method,with 60 cases in each group.The control group was treated with conventional drugs,and the observation group was treated by RIPC on this basis.The serum inflammatory factors,cognitive function and quality of life were compared between the two groups before and after treatment.Results Before treatment,there was no significant difference in serum inflammatory factor level,cognitive function and quality of life between the two groups(P>0.05).After 6 months of treatment,the levels of C-reactive protein,tumor necrosis factor-αand interleukin-16 in the observation group were lower than those in the control group(all P<0.05),the scores of mini mental state scale and Montreal cognition scale in the observation group were higher than those in the control group(all P<0.05),and the scores of physical function,material function,psychological function and social function in the observation group were higher than those in the control group(all P<0.05).Conclusions The application of RIPC therapy in patients with CSVD can better improve the cognitive dysfunction of patients,promote the decline of serum inflammation,and improve the quality of life of patients.