粪便脱落细胞DNA与血CEA和CA19-9在结肠癌术后复发检测中的价值分析

The Value Analysis on Detection of Exfoliative Cells’ DNA in Feces and Serum(CEA and CA19-9)Amidst Post-operative Recurrence of Colonic Cancer

目的:分析粪便脱落细胞脱氧核糖核酸(DNA)与癌胚抗原(CEA)及糖类抗原19-9(CA19-9)在结肠癌术后复发检测中的价值。方法:将结肠癌术后复发患者240例随机分为对照组和观察组,每组120例。对照组患者检测CEA和CA19-9,观察组患者检测粪便脱落细胞DNA,分析2组患者检验特异性与敏感性水平。结果:观察组患者粪便脱落细胞中黏结蛋白聚糖(SDC2)基因阳性检出20例,敏感性为83.33%,特异性为97.92%;对照组患者血CA19-9、血CEA阳性检出数为23例,敏感性为71.88%,特异性为92.05%;结论:检测粪便细胞DNA中SDC2基因阳性表达水平对预防结肠癌术后复发判断准确度更高。

Objective To analyse the value of detection of exfoliative cells’ DNA in feces and serum(CEA and CA19-9)amidst postoperative recurrence of colonic cancer. Methods The 240 patients with colonic cancer suffered from recurrence were randomly divided into control group(120 cases,received detection of CEA and CA19-9)and observation group(120 cases,detected their exfoliative cells’ DNA in feces);then,both groups’ specificity and sensitivity of detection were analysed. Results In observation group 20 cases were detected out SDC2 gene positively,its sensitivity and specificity was respectively 83.33% and97.92%;meanwhile,in control group 23 cases were detected out CEA and CA19-9 positively,its sensitivity and specificity was respectively 71.88% and 92.05%. Conclusion The levels of positive expression of SDC2 gene in feces’ cell DNA has more higher accuracy for prophylactically judging postoperative recurrence of colonic cancer than that of detection of CEA and CA19-9.