布托啡诺联合右美托咪定滴鼻超前镇痛在行腹腔镜胆囊切除术患者中的应用

Application of butorphanol combined with dexmedetomidine for preemptive analgesia to patients undergoing laparoscopic cholecystectomy

目的:探讨布托啡诺联合右美托咪定(Dex)滴鼻超前镇痛在行腹腔镜胆囊切除术(LC)患者中的应用效果。方法:选择行LC治疗的78例患者,按随机数字表法将其分为两组,每组各39例。两组均采用全麻,BD组给予布托啡诺、Dex滴鼻超前镇痛,对照组静脉注射2 ml生理盐水。比较两组应激反应、疼痛程度及不良反应。结果:BD组拔管后30 min的Cor、TNF-α、CRP低于对照组,术后2 h、8 h、12 h时VAS评分低于对照组,恶心/呕吐发生率低于对照组,有统计学差异(P<0.05)。结论:在行LC患者中的应用布托啡诺联合Dex滴鼻超前镇痛,有利于抑制应激反应,可减轻术后疼痛程度,且不良反应少。

Objective: To investigate the effect of butorphanol combined with dexmedetomidine(Dex)nasal drip for preemptive analgesia in patients undergoing laparoscopic cholecystectomy(LC). Methods: 78 patients who underwent LC treatment were randomized into two groups, each with 39 cases. Both groups received general anesthesia. Butorphanol combined with Dex group(BD group)were intranasally administered with butorphanol and Dex for preemptive analgesia, and the control group were injected with 2 ml of normal saline intravenously. The stress response, pain degree and adverse reactions of were compared between patients in the two groups. Results: 30 minutes after extubation, Cor, TNF-α and CRP in the BD group were lower than those of the control group;the VAS scores at 2 h, 8 h, and 12 h after the operation were lower than those of the control group, and the incidence of nausea/vomiting was lower than that of the control group, and the differences were statistically significant(P<0.05). Conclusion: The application of butorphanol combined with Dex nasal drops for preemptive analgesia in patients undergoing LC is beneficial to inhibiting the stress response, reducing the degree of postoperative pain, and it is with fewer adverse reactions.