角膜新生血管治疗研究进展

Advances in corneal neovascularization therapy

角膜新生血管是由多种眼表疾病引起的病理改变,也是常见的致盲因素之一。角膜新生血管通常与炎症、感染、退行性和创伤性疾病有关。角膜新生血管的发生机制与多种细胞信号通路密切相关,深入研究角膜新生血管的发病机制从而寻找抑制其形成的药物,一直是角膜病研究的热点。本文以角膜新生血管形成的发病机制研究为基础,对角膜新生血管当前和新兴的治疗方法进行系统综述。

Corneal neovascularization is a pathological change caused by a variety of ocular surface diseases and is also one of the common causes of blindness.Corneal neovascularization is usually associated with inflammatory,infectious,degenerative and traumatic disorders of the ocular surface.The mechanism of corneal neovascularization is closely related to a variety of cell signaling pathways.It has always been a hot spot in corneal disease research for making further study of the pathogenesis of corneal neovascularization so as to find out drugs to inhibit its formation in depth.This article reviews the pathogenesis of corneal neovascularization and reviews systematically the current and emerging treatment methods for corneal neovascularization.