蝮蛇咬伤患者血清NLR、PLR水平与病情严重程度的相关性

Study on Relationship of Severity of Illness in Patients Bitten by Agkistrodon with Serum NLR and PLR Levels

【目的】探讨蝮蛇咬伤患者血清中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)水平与病情严重程度的相关性。【方法】本院收治的143例蝮蛇咬伤患者,根据纳入及排除标准共选取115例患者为研究对象,根据蛇伤严重性评分量表(SSS)评分分为轻度组(0~3分)45例、中度组(4~7分)40例、重度组(8~20分)30例,另随机选取20例健康体检志愿者为健康对照组。比较各组PLR、NLR、高敏C反应蛋白(hs-CRP)、降钙素原(PCT)、白介素-1(IL-1)、白介素-6(IL-6)水平,并分析NLR、PLR与蝮蛇咬伤患者病情严重程度的相关性。【结果】血清NLR、PLR水平与蝮蛇咬伤严重程度均呈正相关(均P<0.05)。与对照组相比,蝮蛇咬伤中毒各组NLR、PLR水平明显升高(P<0.05)。与轻度组、中度组患者相比,重度组患者中NLR、PLR水平明显升高(P<0.05),与轻度组相比,中度组患者NLR、PLR水平有所升高(P>0.05)。与对照组相比,蝮蛇咬伤中毒各组患者hs-CRP、PCT、IL-1、IL-6水平明显升高(均P<0.05)。与轻度组相比,中度组、重度组hs-CRP、PCT、IL-1、IL-6水平明显升高,但轻度组与中度组比较差异无统计学意义(均P>0.05)。与中度组相比,重度组中hs-CRP、PCT、IL-1、IL-6水平明显升高(均P<0.05)。【结论】NLR和PLR与蝮蛇咬伤患者病情程度呈正相关。

【Objective】To investigate the relationship the severity of agkistrodon bite with neutrophil-to-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)levels in patient serum.【Methods】There are 143 cases of patients bitten by agkistrodon in total who were admitted to our Hospital.Of which,115 patients were selected based on the inclusion and exclusion criteria.According to the Snake Bite Severity Scale(SSS)score,they were divided into 45 cases in the mild group,(0~3 points),40 cases in the moderate group(4~7 points),and 30 cases in the severe group(8~20 points).During the same time period,20 healthy volunteers were randomly selected from Health Management Center and divided into the healthy control group.The levels of NLR,PLR,high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT),interleukin-1(IL-1)and interleukin-6(IL-6)in each group were compared.After that,the relationship of severity of the disease in patients bitten by agkistrodon with levels of NLR and PLR was analyzed.【Results】Serum NLR and PLR were positively correlated with the severity of snake bite(P<0.05).Compared with the control group,the levels of NLR and PLR in the snake poisoning groups were significantly increased(P<0.05).Compared to patients in the mild and moderate groups,the levels of NLR and PLR in the severe group were significantly higher(P<0.05).Compared with the patients in the mild group,the levels of NLR and PLR in the moderate group were Increased(P>0.05).Compared to the control group,the levels of hs-CRP,PCT,IL-1,and IL-6 were significantly higher in the agkistrodon poisoning groups(all P<0.05).Among the poisoning groups,levels of hs-CRP,PCT,IL-1,and IL-6 in the mild group were lower than those in the moderate group and the severe group,however,the difference between the mild group and the moderate group was not statistically significant(All P>0.05)and the difference between the mild group and the severe group was statistically significant(P<0.05).【Conclusion】Both NLR and PLR are positively correlated with the severity of patients bitten by agkistrodon.