MLF1IP在膀胱尿路上皮癌组织中的表达及其临床意义

Expression of MLF1IP in Bladder Urothelial Carcinoma and its Clinical Significance

【目的】探讨人髓细胞白血病因子1相互作用蛋白基因(MLF1IP)在膀胱尿路上皮癌组织中的表达及其临床意义。【方法】选取2015年2月至2017年2月在本院行手术治疗的52例膀胱尿路上皮癌患者,取手术切除的癌组织和癌旁正常组织,并将其分为膀胱尿路上皮癌组(观察组)和癌旁组(对照组)。检测所有研究对象患者癌旁组织及癌组织中MLF1IP mRNA、MLF1IP表达水平,分析MLF1IP mRNA表达水平与膀胱尿路上皮癌临床病理特征的关系,评估MLF1IP mRNA表达水平对膀胱尿路上皮癌患者预后的影响,分析影响膀胱尿路上皮癌患者预后的相关因素。【结果】观察组MLF1IP阳性表达率、MLF1IP mRNA及MLF1IP水平均显著高于对照组(P<0.05)。膀胱尿路上皮癌患者MLF1IP mRNA表达与膀胱尿路上皮癌病理分级及临床分期有关(P<0.05),而与患者性别、年龄、肿瘤直径无关(P>0.05)。MLF1IP mRNA高表达患者术后3年总生存率低于MLF1IP mRNA低表达患者(P<0.05)。MLF1IP mRNA高表达和病理分级是影响膀胱尿路上皮癌患者预后的独立危险因素(P<0.05)。【结论】膀胱尿路上皮癌患者MLF1IP高表达,与患者病理分级、临床分期及预后有关,对评估患者预后具有重要意义。

【Objective】To investigate the expression of human myeloid leukemia factor 1-interacting protein gene(MLF1IP)in patients with bladder urothelial carcinoma.【Methods】A total of 52 patients with bladder urothelial carcinoma who underwent surgery in our hospital from February 2015 to February 2017 were selected.The resected cancer tissues and adjacent normal tissues were taken and divided into bladder urothelial carcinoma group(observation group)and adjacent group(control group).The expression levels of MLF1IP mRNA and MLF1IP in adjacent tissues and cancer tissues of all subjects were detected,the relationship between MLF1IP mRNA expression level and clinicopathological features of bladder urothelial carcinoma was analyzed,the effect of MLF1IP mRNA expression level on the prognosis of patients with bladder urothelial carcinoma was evaluated,and the related factors affecting the prognosis of patients with bladder urothelial carcinoma were analyzed.【Results】The positive expression rate of MLF1IP,MLF1IP mRNA and MLF1IP level in the observation group were significantly higher than those in the control group(P<0.05).The expression of MLF1IP mRNA in patients with bladder urothelial carcinoma was related to the pathological grade and clinical stage of bladder urothelial carcinoma(P<0.05),but not to the patient's gender,age and tumor diameter(P>0.05).The 3-year overall survival rate of patients with high expression of MLF1IP mRNA was lower than that of patients with low expression of MLF1IP mRNA(P<0.05).The high expression of MLF1IP mRNA and pathological grade were independent risk factors affecting the prognosis of patients with bladder urothelial carcinoma(P<0.05).【Conclusion】The high expression of MLF1IP in patients with bladder urothelial carcinoma is related to the pathological grade,clinical stage and prognosis.It is of great significance to evaluate the prognosis of patients.