摘要
Chirality,which is one of the defining features of biological molecules,plays a critical role in many important life processes.Controlled supramolecular assembly of biomolecules into functional structures with low structural fluidity,e.g.,cytoske-leton filaments[1],flagellar filaments of bacteria[2],and high structural fluidity(e.g.,cell membranes[3]),serves key roles in the correct functioning of biological processes.Inspired by natural supramolecular assembly,a large number of discrete two-and three-dimensional chiral polygons with well-defined shapes have been successfully prepared through self-assembly[4-8].
人工手性自组装一直是分子化学与材料化学的前沿挑战性课题.但由于缺少合适的手性光响应结构单元,构造具有光控、可逆、手性专一性响应的分子体系具有很大的挑战性.本工作通过合理的分子设计:以氰基二苯乙烯作为光致异构基团,磺酸基作为亲水基团,胆固醇作为疏水手性基团,构造了独特的光响应组装体系.当氰基二苯乙烯处于反式构型时,在水相中组装形成规则的球状组装体且具有较强的手性信号.通过365 nm光照后,反式构型转变为顺式构型,球状组装体解组装,同时手性信号消失;当采用254 nm光照后,重新形成具有手性信号的球状组装体.核磁共振和吸收光谱结果表明光致异构转化率达到90%,并且具有良好的光致异构重复性(抗疲劳性)及热稳定性.本研究成功实现了水相介质中光控、手性专一性响应的可逆光调控,在构建双稳态光控手性开关方面表现出潜在的应用前景.
基金
supported by the National Natural Science Foundation of China (21875143 and 21908146)
the Innovation Research Foundation of Shenzhen (JCYJ20180507182229597)
the Natural Science Foundation of Guangdong Province (2016A030312002)。
