沙库巴曲沙坦类药-药共晶研究进展

Research Progress of Drug-drug Cocrystals of Sacubitril and Sartans

开发新型药-药共晶的临床应用价值是值得期待的研究领域。近年来,多个药-药共晶药物获得美国和我国药品审评中心上市批准,这使得药-药共晶药物研究成为药物晶型领域的研究热点,药-药共晶成为多靶点药物开发的新思路。沙库巴曲可与多种沙坦类药物在分子水平上形成药-药共晶,该文对沙库巴曲-沙坦类药物共晶的作用机制、结构特征和制备方法等发展情况进行综述。

The clinical application value of developing new drug-drug cocrystals is a field worth looking forward to researching.In recent years,a number of drug-drug cocrystals have been approved for listing by the drug examination centers of the United States and China,which makes the research on drug-drug cocrystals become a hot issue in the field of drug crystal form research,and drug-drug cocrystals has become a new idea of multi-target drug development.Sacubitril can form cocrystals with a variety of sartan drugs at the molecular level.Furthurmore,the development of the preparation methods,structural characteristics and of metabolism is reviewed.In this paper,the mechanism of action,structural characteristics,and preparation methods of sacubitril-sartans cocrystals were reviewed.