喹硫平联合碳酸锂治疗躁狂症的临床效果及对患者相关血清因子水平的影响

Clinical effect of quetiapine combined with lithium carbonate in the treatment of mania and its influence on the levels of related serum factors of patients

目的分析喹硫平联合碳酸锂治疗躁狂症的临床效果及对患者相关血清因子水平的影响。方法选取2018年2月至2020年12月我院收治的80例躁狂症患者为研究对象,根据治疗方案的不同将其分为对照组和研究组,各40例。对照组采用碳酸锂治疗,研究组采用喹硫平联合碳酸锂治疗。比较两组的治疗效果。结果治疗后,两组的BRMS、PANSS评分均降低,且研究组低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的Hcy、5-HT、NE、DA及CK水平均降低,且研究组低于对照组,差异具有统计学意义(P<0.05)。研究组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。结论喹硫平联合碳酸锂治疗躁狂症的效果显著,能有效减轻患者的躁狂症状,降低血清相关因子水平。

Objective To analyze the clinical effect of quetiapine combined with lithium carbonate in the treatment of mania and its influence on the levels of related serum factors of patients.Methods A total of 80 patients with mania treated in our hospital from February 2018 to December 2020 were selected as the research objects and divided into control group and study group according to different treatment plans,with 40 cases in each group.The control group was treated with lithium carbonate,and the study group was treated with quetiapine combined with lithium carbonate.The therapeutic effects of the two groups were compared.Results After treatment,BRMS and PANSS scores in both groups decreased,and those in the study group were lower than the control group,the differences were statistically significant(P<0.05).After treatment,the levels of Hcy,5-HT,NE,DA and CK in both groups decreased,and those in the study group were lower than the control group,the differences were statistically significant(P<0.05).The total effective rate of treatment in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Quetiapine combined with lithium carbonate has a significant effect on the treatment of mania,which can effectively relieve the symptoms of mania and reduce the levels of related serum factors.