脑蛋白水解物联合果糖二磷酸钠片治疗急性脑梗死的临床效果

Clinical effect of cerebroprotein hydrolysate combined with sodium fructose diphosphate tablets in the treatment of acute cerebral infarction

目的探讨脑蛋白水解物联合果糖二磷酸钠片治疗急性脑梗死(ACI)的临床效果。方法回顾性分析我院2015年9月至2019年8月收治的120例ACI患者的临床资料,根据治疗方案的不同将患者分为对照组(60例,果糖二磷酸钠片)和观察组(60例,脑蛋白水解物+果糖二磷酸钠片)。比较两组的治疗效果、血清炎性因子(TNF-α、IL-6、IL-8)、血管内皮功能指标(sEPCR、vWF)、血小板活化指标(CD62p、CD63)、miR-124、miR-181c表达水平。结果观察组的治疗总有效率明显高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的血清TNF-α、IL-6、IL-8水平明显低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的血清sEPCR、vWF水平明显低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的血清CD62p、CD63水平明显低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的血清miR-124、miR-181c表达水平明显低于对照组,差异具有统计学意义(P<0.05)。结论脑蛋白水解物联合果糖二磷酸钠片治疗ACI的临床效果显著,可调节血清sEPCR、vWF、miR-124、miR-181c表达,减轻炎性反应,降低血小板活化程度,值得临床推广和应用。

Objective To investigate the clinical effect of cerebroprotein hydrolysate combined with sodium fructose diphosphate tablets in the treatment of acute cerebral infarction(ACI).Methods The clinical data of 120 ACI patients admitted in our hospital from September 2015 to August 2019 were retrospectively analyzed,and the patients were divided into control group(60 cases,sodium fructose diphosphate tablets)and observation group(60 cases,cerebroprotein hydrolysate+sodium fructose diphosphate tablets)according to different treatment plans.The therapeutic effect,serum inflammatory factors(TNF-α,IL-6,IL-8),vascular endothelial function indexes(sEPCR,vWF),platelet activation indexes(CD62p,CD63),miR-124 and miR-181c expression levels were compared between the two groups.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of serum TNF-α,IL-6 and IL-8 in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the serum sEPCR and vWF levels in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of serum CD62p and CD63 in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the expression levels of serum miR-124 and miR-181c in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Cerebroprotein hydrolysate combined with sodium fructose diphosphate tablets in the treatment of ACI has a significant clinical effect,it can regulate the expression of serum sEPCR,vWF,miR-124 and miR-181c,alleviate the inflammatory response,and reduce the degree of platelet activation,which is worthy of clinical promotion and application.