不同剂量右美托咪定复合咪达唑仑滴鼻在小儿腹股沟疝手术中的麻醉效果及对应激反应、苏醒质量的影响

Anesthetic effect of different doses of dexmedetomidine combined with midazolam nasal drops in children with inguinal hernia surgery and its influences on stress response and awakening quality

目的探讨不同剂量右美托咪定复合咪达唑仑滴鼻在小儿腹股沟疝手术中的麻醉效果。方法选取2020年1月至2021年4月我院收治的80例腹股沟疝手术患儿作为研究对象,以随机数字表法将其分为A组和B组,各40例。A组麻醉诱导前30 min采用0.5μg/kg右美托咪定复合咪达唑仑滴鼻,B组麻醉诱导前30 min采用1.0μg/kg右美托咪定复合咪达唑仑滴鼻。比较两组的麻醉效果、应激反应指标、苏醒质量。结果T_(2)~T_(4)时,B组的OAA/S评分低于A组,差异具有统计学意义(P<0.05)。T_(1)~T_(4)时,B组的Cor、NE水平低于A组,差异具有统计学意义(P<0.05)。两组的苏醒时间、拔管时间、离开恢复室时间无明显差异(P>0.05)。结论相较于0.5μg/kg右美托咪定复合咪达唑仑滴鼻,1.0μg/kg右美托咪定复合咪达唑仑滴鼻在小儿腹股沟疝手术中的麻醉效果更好,应激反应更轻微。

Objective To investigate the anesthetic effect of different doses of dexmedetomidine combined with midazolam nasal drops in children with inguinal hernia surgery.Methods A total of 80 children with inguinal hernia surgery admitted in our hospital from January 2020 to April 2021 were selected as the research objects.The children were divided into group A and group B by random number table method,with 40 cases in each group.The group A used 0.5μg/kg dexmedetomidine combined with midazolam nasal drops at 30 min before anesthesia induction,and the group B used 1.0μg/kg dexmedetomidine combined with midazolam nasal drops at 30 min before anesthesia induction.The anesthetic effect,stress response indexes and awakening quality of the two groups were compared.Results From T_(2) to T_(4),the OAA/S score of the group B was significantly higher than that of the group A,and the difference was statistically significant(P<0.05).From T_(1) to T_(4),the levels of Cor and NE in the group B were lower than those in the group A,and the differences were statistically significant(P<0.05).There were no significant differences in recovery time,extubation time and time of leaving recovery room between the two groups(P>0.05).Conclusion Compared with 0.5μg/kg dexmedetomidine combined with midazolam nasal drops,1.0μg/kg dexmedetomidine combined with midazolam nasal drops has better anesthetic effect in children with inguinal hernia surgery and less stress response.