猫爪草对肺结核患者肝功能的调控作用

Regulatory effect of Ranunculus ternatus on liver function of pulmonary tuberculosis patients

目的探讨猫爪草对肺结核患者肝功能的调控作用。方法选取2019年8月至2020年8月就诊于赣州市第五人民医院诊断为肺结核,且使用四联(异烟肼、利福平、吡嗪酰胺、乙胺丁醇)抗结核药物的80例患者为研究对象,按照随机数字表法分为观察组和对照组,各40例。针对肝脏功能保护,对照组服用当飞利肝宁胶囊,观察组给予猫爪草,比较两组治疗后肝功能相关指标及肝脏纤维化相关指标变化情况,统计两组治疗期间肝功能异常首发时间和肝功能恢复正常时间,比较两组抗结核治疗临床效果。结果观察组肝功能指标中谷丙转氨酶(ALT),谷草转氨酶(AST),总胆红素(TBil)水平均低于对照组,差异有统计学意义(P<0.05),观察组肝脏纤维化相关指标中透明质酸(HA)和Ⅲ型前胶原(PCⅢ)水平均低于对照组,差异有统计学意义(P<0.05),观察组肝功能恢复正常时间早于对照组,差异有统计学意义(P<0.05),随访半年期间观察组痰菌转阴率及胸片吸收好转率均高于对照组,差异有统计学意义(P<0.05)。结论使用猫爪草对长时间接受抗结核药物治疗患者进行肝功能调控,能有效改善患者肝功能,抑制肝脏纤维化形成,并达到提高临床抗结核治疗效果。

Objective To explore the value of Ranunculus ternatus on liver function of pulmonary tuberculosis patients.Methods A total of 80 cases who was diagnosed as tuberculosis in the tuberculosis ward in the Fifth People′s Hospital of Ganzhou City from August 2019 to August 2020 were used tetralogy(Isoniazid,Rifampicin,Pyrazinamide,Ethambutol)anti-tuberculosis drugs and divided into Observation group and control group according to random number table method,with 40 cases in each group.For liver function protection,the control group was given Dangfeiliganning Capsule,the observation group was given Ranunculus ternatus.Then the changes of liver function related indexes and liver fibrosis related indexes between the two groups were ompared,count the first time of abnormal liver function and the time of liver function recovery during treatment,the clinical effect of anti-tuberculosis treatment between the two groups were compared.Results The levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBil)in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05),and the levels of hyaluronic acid(HA)and procollagenⅢ(PCⅢ)in the related indexes of liver fibrosis in the observation group were lower than control group,the differences were statistically significant(P<0.05).The liver function in the observation group recovered earlier than control group,and the difference was statistically significant(P<0.05).During the follow-up period of half a year,the sputum bacteria conversion rate and chest film absorption improvement rate in the observation group were higher than control group,and the differences were statistically significant(P<0.05).Conclusion The use of Ranunculus ternatus to regulate the liver function of patients who have been treated with anti-tuberculosis drugs for a long time can effectively improve the liver function of patients and inhibit the formation of liver fibrosis and improve the clinical anti-tuberculosis treatment effect.