肿瘤相关自身抗体联合肿瘤标志物对肺癌的诊断价值

Diagnostic value of tumor associated autoantibodies combined with tumor markers in the lung cancer

目的探究血清7种肿瘤相关自身抗体(7-TAABs)和肿瘤标志物联合检测对肺癌的诊断价值。方法选取2020年12月至2021年7月西安交通大学第一附属医院收治的肺癌患者149例为肺癌组,选取同期肺部良性疾病患者86例为对照组。比较两组患者p53、PGP9.5、SOX2、GAGE7、GBU4-5、MAGE-A1、CAGE抗体和3项肿瘤标志物[鳞状上皮细胞癌抗原(SCC)、癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)]水平,分析7-TAABs和肿瘤标志物对肺癌的诊断效能。结果肺癌组患者血清中3项肿瘤标志物和7-TAABs中的p53、PGP9.5、SOX2、GAGE7、GBU4-5、MAGE-A1水平均高于对照组,差异有统计学意义(P<0.05)。7-TAABs联合3项肿瘤标志物联合检测的阳性率高于对照组,差异有统计学意义(P<0.05)。7-TAABs联合3项肿瘤标志物联合检测的灵敏度、准确度、阴性预测值最高,分别为83.22%、79.15%、71.26%。结论7-TAABs与传统肿瘤标志物联合检测可提高诊断效能,为肺癌的诊断和筛查提供依据。

Objective To explore the diagnostic value of serum 7 tumor associated autoantibodies(7-TAABS)and tumor markers in lung cancer.Methods A total of 149 patients with lung cancer admitted to the First Affiliated Hospital of Xi′an Jiao Tong University from December 2020 to July 2021 were selected as the lung cancer group,and 86 patients with benign lung disease were selected as the control group.The levels of p53,PGP9.5,SOX2,GAGE7,GBU4-5,MAGE-A1,CAGE antibodies and 3 tumor markers(squamous cell carcinoma[SCC],carcinoembryonic antigen[CEA]and cytokeratin 19 fragment[CYFRA21-1])were compared between two groups,the diagnostic efficacy of 7-TAABs and tumor markers in lung cancer were analyzed.Results Serum levels of 3 tumor markers and p53,PGP9.5,SOX2,GAGE7,GBU4-5 and MAGE-A1 in 7-Taabs in lung cancer group were higher than those in control group,the differences were statistically significant(P<0.05).The positive rate of 7-TAABS combined with 3 tumor markers was higher than that of the control group,the difference was statistically significant(P<0.05).The sensitivity,accuracy and negative predictive value of 7-TAABS combined with 3 tumor markers were 83.22%,79.15%and 71.26%,respectively.Conclusion The combined detection of 7-TAABs and traditional tumor markers can improve the diagnostic efficiency and provide basis for the diagnosis and screening of lung cancer.