血清Furin、Nesfatin-1水平与急性ST段抬高型心肌梗死预后的关系

Relationship between serum Furin,Nesfatin-1 and prognosis of patients with acute ST-segment elevation myocardial infarction

目的:探讨血清弗林蛋白酶(Furin)、摄食抑制因子-1(Nesfatin-1)与急性ST段抬高型心肌梗死(STEMI)预后的关系。方法:选取2018年1月至2020年1月在我院行急诊经皮冠状动脉介入治疗(PCI)的急性STEMI患者132例(设为心肌梗死组),术后随访6个月,根据患者是否发生主要心血管不良事件(MACE),分为MACE组(95例)和无MACE组(37例);另选取我院体检健康志愿者100例作为对照组。采用酶联免疫吸附法检测血清Furin、Nesfatin-1水平。采用多因素Logistic回归分析影响急性STEMI患者MACE发生的危险因素。结果:心肌梗死组血清Furin、Nesfatin-1水平与对照组比较差异有统计学意义(P<0.05)。MACE组血清Furin水平高于无MACE组,Nesfatin-1水平低于无MACE组,差异均有统计学意义(均P<0.05)。多因素Logistic回归分析显示,血清Furin水平升高、Nesfatin-1水平降低是急性STEMI患者MACE发生的独立危险因素(P<0.05)。受试者工作特征(ROC)曲线分析显示,血清Furin、Nesfatin-1及二者联合检测预测急性STEMI患者MACE发生的曲线下面积(AUC)分别为0.795、0.819及0.897。结论:急性STEMI患者血清Furin水平升高、Nesfatin-1水平降低,其是患者MACE发生的重要危险因素,可作为判断患者预后状态的辅助参考指标。

Objective:To investigate the relationship between serum furin(Furin),feeding inhibitor-1(Nesfatin-1)and the prognosis of patients with acute ST-segment elevation myocardial infarction(STEMI).Methods:A total of 132 patients with acute STEMI who underwent emergency PCI treatment in our hospital from January 2018 to January 2020(myocardial infarction group)were selected.The patients were followed up for 6 months after operation.According to whether the patients had major adverse cardiovascular events(MACE),they were divided into MACE group(n=95)and MACE-free group(n=37).In addition,100 healthy volunteers undergoing physical examination in our hospital were selected as control group.Enzyme-linked immunosorbent assay was used to detect serum Furin and Nesfatin-1 levels.Multivariate logistic regression analysis was used to analyze the risk factors affecting the occurrence of MACE in patients with acute STEMI.Results:Compared with the control group,the serum Furin and Nesfatin-1 levels in the myocardial infarction group were significantly different(P<0.05).Serum Furin level in MACE group was higher than that in MACE-free group,and serum Nesfatin-1 level in MACE group was lower than that in MACE-free group,the difference being statistically significant(P<0.05).Multivariate logistic regression analysis showed that increased serum Furin levels and decreased Nesfatin-1 levels were independent risk factors for MACE in patients with acute STEMI(P<0.05).ROC curve results showed that serum Furin,Nesfatin-1 and the combined detection of the two in predicting the AUC of MACE in patients with acute STEMI were 0.795,0.819 and 0.897 respectively.Conclusion:Serum Furin levels increase and Nesfatin-1 levels decrease in patients with acute STEMI,which are important risk factors for MACE.It can be used as an auxiliary reference index in judging the prognosis of patients.