载姜黄素纳米金微球的制备及缓释性能研究

Preparation and Slow-release Property of Curcumin-loaded Gold Nanoparticles

以HAuCl;和十六烷基三甲基溴化铵(CTAB)分别作为Au源和表面活性剂,采用晶种生长法制备Au纳米微球,经硅烷偶联剂表面修饰并进一步装载姜黄素,探究Au纳米微球负载Cur的载药及缓释性能,利用FTIR、XRD、SEM等分析技术对所制备材料的理化性质进行表征。结果表明,成功制备以Au为载体的姜黄素纳米金微球,与姜黄素作对比,姜黄素突释明显,在6 h完全释放,而Cur-Au在6 h释放率为17%,表明经修饰后的Au纳米微球作为载体具有药物缓释的作用。

Using HAuCl;as Au source and cetyltrimethylammonium bromide(CTAB)as surfactant, Au nanospheres were prepared by seed growth method. After surface modification with silane coupling agent and further loading with curcumin, the drug loading and slow-release properties of Cur supported by Au nanoparticles were investigated. The physical and chemical properties of the prepared materials were characterized by FTIR, XRD and SEM. The results showed that the curcumin nanomicrospheres with Au as the carrier were successfully prepared. The modified nanoparticles had good drug loading performance. Compared with curcumin, Cur-Au release rate was 17% at 6 h, while pure curcumin was completely released at 6 h, indicating that the modified gold nanoparticles as carriers had the effect of drug slow-release.