基于“火与元气不两立”论肿瘤恶病质

On cancer cachexia based on “Yin-pathogenic fire and primordial qi are opposites”

元气与火作为能量代谢必备的物质基础与动力,其失态与肿瘤恶病质的病理机制密切相关。元气亏虚是肿瘤恶病质内耗的根源,阴火无制是肿瘤恶病质进展的关键,此与李东垣提出的“火与元气不两立,一胜则一负”的气火关系失调病机相契合。元气亏虚,精微生转无源,阴火无制,阳气弥散缺失,为肿瘤恶病质异常代谢提供内环境与动力,此与西医学肿瘤恶病质的发生发展机理有相似之处。故在补元气、泻阴火治则指导下,以风药助阳、豁痰、行瘀为治疗挈要,令火与元气各守其位,从而延缓肿瘤恶病质的发展进程,以期为临床治疗肿瘤恶病质提供思路与借鉴。

“Primordial qi” and “fire” are the necessary material basis and power of energy metabolism.Their misbehavior is closely related to the pathomechanism of cancer cachexia.Deficiency of primordial qi is the root of the internal friction of cancer cachexia,and the hyperactive fire is the key to the development of cancer cachexia,which is in accordance with the pathogenesis of maladjustment of the relationship between primordial qi and fire proposed by Li Dongyuan:“Yin-pathogenic fire and primordial qi are opposites,one victory leads to one loss.” There is no material basis for the essentialwater-food metabolism;because of the deficiency of primordial qi,the hyperactive fire causes the yang qi to fail to diffuse,and these phenomena provide an internal environment and power for abnormal metabolism in cancer cachexia,which is similar to the pathogenesis of cancer cachexia as described by modern medicine.In this way,the method of primordial qitonification and Yin-pathogenic fire purgation is the general principle,with the key point being that the power of wind medicine assists yang,resolves phlegm and stasis.As such,fire and primordial qi are kept in their respective positions to prevent the progression of cancer cachexia,thus providing ideas and a theoretical basis for clinical intervention of tumor cachexia.