长链非编码RNA在成骨分化相关信号通路中的调控作用

Regulation of long non-coding RNA in signal pathways related to osteogenic differentiation

目的 总结长链非编码RNA(long non-coding RNA,lncRNA)在成骨分化相关信号通路中的作用机制。方法 广泛查阅近年国内外相关研究文献,介绍lncRNA的特征和生物学功能,详细阐述lncRNA在成骨分化中调控相关信号通路的具体机制。结果 骨组织正常功能的发挥及维持需要转录网络和信号通路的紧密协调,在影响骨稳态的病理条件下,这些信号通路或网络大部分失调。lncRNA可通过激活或抑制信号通路调控各种骨细胞分化来达到骨稳态平衡,从而逆转骨骼的病理状态,达到治疗骨代谢性疾病的目的。结论 目前关于lncRNA调控各成骨分化的通路机制研究仍处于早期阶段,其具体作用机制,尤其是复杂信号通路的交联,有待进一步研究。此外,如何将这些分子靶标应用于临床治疗也是一大挑战。

Objective To summarize the mechanism of long non-coding RNA(lncRNA) in signal pathways related to osteogenic differentiation. Methods Relevant domestic and foreign researches in recent years were consulted.The characteristics and biological functions of lncRNA were introduced, and the specific mechanism of lncRNA regulating related signal pathways in osteogenic differentiation was elaborated. Results The exertion and maintenance of normal function of bone requires the closed coordination of transcription networks and signal pathways. However,most of these signal pathways or networks are dysregulated under pathological conditions that affect bone homeostasis.lncRNA can regulate the differentiation of various bone cells by activating or inhibiting signal pathways to achieve the balance of bone homeostasis, thereby reversing the pathological state of bones and achieving the purpose of treating bone metabolic diseases. Conclusion At present, the research on the mechanism of lncRNA regulating various osteogenic differentiation pathways is still in the early stage. Its in-depth regulator mechanism, especially the cross-talk of complex signal pathways needs to be further studied. And how to apply these molecular targets to clinical treatment is also a big challenge.