四面体框架核酸在骨关节炎治疗中的应用前景

Application of tetrahedral framework nucleic acids in the treatment of osteoarthritis

目的 介绍四面体框架核酸(tetrahedral framework nucleic acids,tFNA)的特点,重点综述其在骨关节炎(osteoarthritis,OA)治疗中的应用现状,以及与微小RNA(microRNA,miRNA)之间作用的联系,进一步展望tFNA在OA治疗中的应用前景,以及构建miR-tFNA功能化复合体治疗OA的新思路。方法 查阅国内外关于tFNA的最新研究,分析tFNA作用机制及与OA、miRNA的联系。结果 tFNA作为一种新型载体,不仅可以作为具有治疗作用的小分子载体而间接发挥OA治疗作用,其本身也可以通过调节软骨细胞发挥直接治疗作用。tFNA与miRNA结合性良好,构建搭载miRNA的tFNA功能化复合体治疗效果已在多种疾病中得到验证,且与其他载体相比tFNA具有优势。结论 tFNA是一种新型的框架核酸结构,在OA治疗中发挥重要作用。构建miR-tFNA功能化复合体可能是OA治疗的一条新思路。

Objective To introduce the characteristics of tetrahedral framework nucleic acids(tFNA), focusing on its application in the treatment of osteoarthritis(OA) and relationship with microRNA(miRNA), and prospect the application of tFNA in the treatment of OA and the new idea of constructing miR-tFNA functional complex to treat OA.Methods Recent studies were extensively reviewed to analyze the mechanism of tFNA and its relationship with OA and miRNA. Results tFNA, a new type of new carrier, can not only play an indirect role in the treatment of OA as a small molecular carrier with therapeutic effect, but also play a direct role through the regulation of chondrocytes. It can bind with the miRNA that can regulate OA. The therapeutic effect of constructing tFNA functional complex loaded with miRNA has been verified in various diseases, and tFNA has advantages compared with other vectors. Conclusion tFNA,a novel framework nucleic acid structure, plays an important role in the treatment of OA. Constructing miR-tFNA functional complex may be an innovative idea in the treatment of OA.